Purpose of the study.The study of the periodont-protective properties of the complex of a mixture of active metabolites of cholecalciferol - 1,25 (OH)2D3 and 24,25(OH)2D3 with a synthetic analogue of vitamin K - vikasol in experimental periodontitis in rats.Materials and cartoon martian with big head methods The study was carried out on 18 white male rats for 1.5 months age, divided into 3 groups.Group 1 (4 individuals) comprised intact rats.
In the rats of the 2nd and 3rd groups (7 individuals each), the parodontitis model was reproduced by oral administration of a 10% solution of pelentane, and also by replacing drinking water with a 2% solution of EDTA ad libitum.In group 3, rats were pentair hose injected daily with a mixture of hormonal forms of vitamin D3 (1,25 (OH)2D3 and 24,25(OH)2D3) against a background of combined effects of pelentane and EDTA.The duration of the experiment was 60 days.Results and conclusions.It is established that the complex of a mixture of two hormonal-active forms of cholecalciferol with vikasol has significant periodontoprotective properties.
The obtained data substantiate the inclusion of vitamin D3 in the composition of perioodontoprotective agents in the treatment of periodontitis.